Diagnostics of Invasive Aspergillosis:
From Experimental Models to Clinical Evaluation
2009 Combined
IAAM and AsTeC Workshop
November 16, 2009
8:30 AM to
5:00 PM
Click highlighted names to
download a PDF file of the speaker’s presentation
1.
Welcome and Greetings by NIAID (Dennis Dixon, Rory Duncan, Alec Ritchie)
2.
AsTeC and IAAM Project overview (Tom Patterson, John Wingard)
Preclinical
studies and the transition to Clinical
3.
Animal model development and refinement
Non-neutropenic
animal models of IPA (Scott
Filler, Laura Najvar, Peter
Warn)
Colonization
model (Don Sheppard)
Utility of
serial markers in serum, blood and BAL fluid (Nathan Wiederhold)
4.
Diagnostic Markers of Infection – Preclinical experience
European
PCR Standardization process overview (Lewis White)
Standardization
of PCR Methodologies (Brian
Wickes, Monica Herrera)
5. Selected new diagnostic targets
and methods
Urinary
Lateral Flow Device (Kieren
Marr)
Multiplexed Microbead Array
Detection of Aspergillosis and Other Invasive Fungi
(Frank Merante)
Detection
of Proteolytic Activity for Diagnostics (Amit Galande)
Immunoassay
for Diagnostics (Tom Kozel)
Aspergillus Antibody Detection (David Denning, Neil Clancy)
Characterization, Identification, and
Comparative Proteomic Kinetics of Innate
Host Defense Proteins in Experimental IPA and Pseudomonas Pneumonia (Tom Walsh)
6.
Gene Expression for Diagnostics:
Experience with respiratory viruses (Aimee Zaas)
7.
Overview of the AsTeC: Progress to Date (John Wingard)
8.
Pre-IDE Submission (Barbara
Alexander)
9.
Developing a Calibrator for Aspergillus
Diagnostics
The
need and approach: lessons learned from other pathogens and
the AsTeC/IAAM plan
for developing a calibrator for Aspergilllus
(Angie Caliendo)
10. Contamination/Stability Testing (David Denning)
11. AsTeC Case Adjudication (Lindsey Baden)
12. Manufacturer Application
Process (Joe Wheat)
13. Panel Discussion plus Q&A (Moderators: Tom Patterson, John
Wingard)
(Barbara Alexander, Angie
Caliendo, Kieren Marr, Lewis White, Brian Wickes, Aimee Zaas, Freddie Poole)
14. Next steps, Q & A (Tom Patterson, John
Wingard)